Latest How To Guides

Since the discovery of elevated levels of nitrosamines in certain pharmaceuticals, reported in July 2018, finding the right solutions have become a major focus for many pharmaceutical manufacturers, particularly as they are considered probable human carcinogens.

This guide explores the critical role of ubiquitin in two protein degradation systems, the ubiquitin-proteasome system (UPS) and the autophagy–lysosomal system (ALS), in proteostasis.

The journey to discovering novel drug targets starts with building a deep understanding of the underlying biology. To achieve this, researchers are increasingly looking to 3D cell cultures to bridge the gap between 2D cell cultures and in vivo animal models.

This guide highlights the four major stages of targeted protein degradation, the challenges at each step, and the questions you should ask yourself to ensure your final product will result in a complete protein degradation.

Mitochondrial toxicity assessments are crucial to ensuring the safety and efficacy of candidate compounds during drug development.

Download this guide to discover tips on sample preparation, fluorescence, fluorochromes and your antigens, your cytometer and data analysis.

Download this guide to learn more about laboratory automation and the novel informatics solutions available to ensure sound and long-lasting investments.

Download this guide to learn more about automated software and the latest solutions available.

Download this guide to learn more about automated liquid handling solutions.

Download this guide to discover how data integrity is fundamental to quality assurance, process development and production, and analytical development and quality control.