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A group of cancer cells shown in red, the target of the newly developed CAR T-cell therapy.
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Next-Generation CAR T-Cell Therapy Designed for Hard-To-Treat Cancers

Researchers at the University of Colorado Anschutz Medical Campus have successfully developed an iteration of CAR-T cell therapy that can enhance the effectiveness and longevity of the cells, particularly against hard-to-treat cancer cells.
Protein structure.
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Temperature May Control Protein Shapeshifting

Scientists propose that temperature is a key trigger for metamorphic proteins, enabling them to switch between shapes. Their study suggests temperature-dependent hydrophobic interactions drive this transformation.
Model of a human brain for Alzheimer's research.
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Common Herbs Inspire a Potential Anti-Inflammatory Alzheimer’s Drug

Scripps Research scientists have created a stable form of carnosic acid, a compound found in rosemary and sage, observing greater memory function and other disease improvements in mice.
Brain cells (magenta) in the reward center of a rat’s brain release dopamine in response to opioids.
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Estrogen May Protect Against Opioid Misuse in Chronic Pain

A study finds that male rats in chronic pain escalate fentanyl use, while females maintain stable doses due to estrogen’s effects. Pain amplified dopamine release in males, driving increased opioid-seeking behavior.
A doctor pointing to brain scans to diagnose neurodegeneration.
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Repurposed ALS Drug Helps Diagnose Neurodegeneration

Scientists at St. Jude Children’s Research Hospital have used positron emission tomography (PET) with edaravone, a drug used to treat ALS, to detect oxidative stress, which leads to brain damage.
Close-up of a cannabis plant.
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Consuming THC While Pregnant May Impact Fetal Lung Development

Oregon Health & Science University researchers have found that consuming cannabis while pregnant could affect fetal lung development and function, potentially leading to the development of chronic respiratory health conditions.
A model of a heart showing the various valves and heart muscle.
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Novel Method To Regenerate Heart Muscle Offers Hope for Heart Failure Treatment

A discovery in cardiac regeneration offers ew hope for the treatment of ischemic heart failure. Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation.
Mould blooms thickly on a yellow surface.
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Strains of Aspergillus fumigatus Five Times More Likely To Acquire Resistance to Antifungals

Researchers have identified strains of one of the world's most dangerous pathogens that are five times more likely to acquire antifungal resistance.
A hand reaches towards a fire.
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Heat-Activated Receptor Could Unlock New Pain Therapies

Researchers have uncovered a heat-based activation mechanism for a critical pain receptor, opening new avenues for therapeutic targets that treat pain.
A cross section of whole skeletal muscle tissue.
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Melatonin Protects Muscle From Damage Caused by Obesity and Diabetes

Researchers show that melatonin improves muscle energy efficiency and could become an innovative therapy to combat obesity and type 2 diabetes.
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