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Drug Repurposing

This page provides educational resources, events, news and products related to drug repurposing, including methodologies, successes and challenges. Content will cover aspects from in silico and activity-based screening and on-target versus off-target drug repurposing strategies, to disease versus therapeutic target approaches.

Drug Repurposing – Highlights

Drug Repurposing Could Open the Door to New Therapies content piece image

Drug Repurposing Could Open the Door to New Therapies

Drug discovery and development is expensive, time-consuming and complex. One approach that is proving productive is drug repurposing powered by artificial intelligence and machine learning.

Drug–Target Binding: Recent Research Developments

Being able to accurately predict drug–target interactions (DTIs) and drug–target binding affinity (DTBA) is crucial in early drug development and during drug repurposing endeavors. Here, we look at some recent research developments in this space.

Drug Repurposing: Advantages and Key Approaches

In this article, we highlight some benefits related to the repositioning of drugs and provide some examples of areas exploiting this approach.

Drug Repurposing: Applying Yesterday's Solutions to Tomorrow’s Problems

We have accepted the importance of recycling such that it has become a part of our culture but adopting the same mindset in the world of pharmaceuticals has been anything but easy.

Drug Repurposing Strategies, Challenges and Successes

In this article, we explore the evolution of drug repurposing from a serendipitous occurrence to a more formalized endeavor involving advanced computational approaches and bioengineered test beds, considering its advantages, challenges and successes.

Drug Repurposing – News and Features

Repurposed Drug Shows Promise as a High-Grade Glioma Treatment

Avapritinib, an FDA-approved drug used to treat other types of cancer, also decreases aggressive gliomas in animal models and in an initial cohort of patients with high-grade glioma.

Blood Pressure Drug Could Be Repurposed for ADHD

A study published in Neuropsychopharmacology found that repurposing amlodipine, a commonly used blood pressure medicine, could offer a promising new pathway to address ADHD symptoms.

Cancer Growth Linked to Nerve Signals, Study Finds

Researchers have discovered that stomach cancers make electrical connections with nearby sensory nerves and use these malignant circuits to stimulate the cancer’s growth and spread.

Antidepressant Protects Against Infection and Sepsis in Mice

Antidepressants have been shown to regulate the immune system and defend against infectious diseases, offering a new avenue for life-saving treatments.

Organoids, Beyond the Hype

The HUMANOID Center at UC San Diego is pioneering organoid research aimed at improving the reliability and reproducibility of these models, ultimately increasing drug testing accuracy and revolutionizing biomedical science.

AI Drug Repurposing Helps Find Medicine for Rare Disease

After combing through 4,000 existing medications, an artificial intelligence tool helped uncover one that saved the life of a patient with Castleman's disease.

Drug Repurposing – Multimedia

Development of an AlphaLISA Protein-Protein Interaction Assay To Screen for Re-Purposed Drugs as Targeted Disruptors content piece image

App Note / Case Study

Development of an AlphaLISA Protein-Protein Interaction Assay To Screen for Re-Purposed Drugs as Targeted Disruptors

Study Identifies Several Existing Drugs As Potential COVID-19 Therapies content piece image

Study Identifies Several Existing Drugs As Potential COVID-19 Therapies

Repurposing Drugs for COVID-19 Using High-Throughput Screening content piece image

Repurposing Drugs for COVID-19 Using High-Throughput Screening

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