Episode 2: Effective Metabolism for T cells to Persist in the Solid Tumor Microenvironment
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Immune cells are exposed to profound metabolic distress in the solid tumor microenvironment and the ability to overcome this stress largely determines the efficacy of tumor immunotherapies.
In the second episode of Agilent’s Cancer Metabolism webinar series, Dr. Jessica E. Thaxton will discuss recent findings on how modulating T cells’ metabolic program towards a greater reliance on lipid utilization and fatty acid oxidation enhances anti-tumor function in the tumor microenvironment. Results explore the role of Acetyl-CoA Carboxylase (ACC) to hinder lipid utilization in T cells in solid cancers, limiting anti-tumor immunity.
- Metabolic challenges immune cells face in the solid tumor microenvironment and their impact on tumor immunotherapy efficacy
- Modulating T cell metabolic programs toward lipid utilization and how fatty acid oxidation enhances anti-tumor function
- The role of ACC in restricting lipid utilization in T cells and its implications for anti-tumor immunity in solid cancers
