Episode 5: Nutrients and Metabolites Controlling Natural Killer Cell Responses
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In the final episode of Agilent’s Cancer Metabolism webinar series, Dr. David Finlay will discuss the importance of cellular metabolism for Natural Killer (NK) responses to tumours and viral infection.
A number of signalling pathways have been identified as crucial in controlling NK cell metabolic and functional responses. Interestingly, the levels of nutrients and metabolites within the immune microenvironment can affect these key signalling pathways as well as cellular metabolism directly. This likely contributes to the NK cell dysfunction associated with certain disease states such as cancer. Engineering NK cells to be metabolically resilient for improved effector function in inhospitable microenvironments is an exciting prospect for developing improved NK cell based immunotherapies.
Attend this episode to learn about:
- NK cell metabolism
- How different nutrients and metabolites affect NK cell responses
- The potential for metabolic engineering of NK cells for improve immunotherapies
