Learn How the Brain Ages at the Cellular Level

Explore the science of brain aging in this episode of Teach Me in 10.

Join Dr. Kelly Jin, a scientist at the Allen Institute for Brain Science, as she discusses new research on how our brains change as we age. Dr. Jin talks about a newly released dataset that reveals how specific brain cell types – like microglia, oligodendrocytes and neurons – undergo gene expression shifts over time, with key changes concentrated in the hypothalamus, a crucial brain region for metabolism and inflammation.

Learn how advanced tools like single-cell RNA sequencing are enabling scientists to map over a million brain cells, comparing young and aged mice to uncover potential "aging hot spots”.

If you're interested in neuroscience and aging, this episode is for you!

Want to learn more about age-related changes in the brain?

• Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
• Brain cell changes linked to aging identified
• Understanding single-cell sequencing, how it works and its applications
• Zeng aging mouse 10Xv3 single cell transcriptomes