Episode 3: What Fuels CAR T Cell Serial Killing
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For cellular immunotherapies such as CAR T cells, clinical outcomes depend on the cytolytic potency and metabolic fitness of the therapeutic product. For their most effective indications, CAR T cells are effective serial killers; each CAR T cell can recognize and lyse several tumor cells. Moreover, what supports the energy cost of synapse formation versus migration, two critical events that underlie serial killing are poorly understood.
In the third episode of Agilent’s Cancer Metabolism webinar series, Dr. Roddy O’Connor introduces “hit & run” serial killing as a conceptual framework underpinning CAR T cell function and will introduce novel approaches to study how metabolic reprogramming impacts the migratory versus cytolytic aspect of killing.
Attend this episode to learn about:
- Mechanisms of CAR T cell function, including how they act as "serial killers" capable of lysing multiple tumor cells
- The concept of "hit & run" serial killing and how this impacts the effectiveness of CAR T cells
- Energy requirements for CAR T cell synapse formation versus migration and how metabolic reprogramming influences these aspects of killing
